The Spatiotemporal Organization of the Striatum Encodes Action Space. Neuron. 2017
Klaus A, Martins GJ, Paixao VB, Zhou P, Paninski L, Costa RM.
Abstract
Activity in striatal direct- and indirect-pathway spiny projection neurons (SPNs) is critical for proper movement. However, little is known about the spatiotemporal organization of this activity. We investigated the spatiotemporal organization of this activity. We investigated the spatiotemporal organization of SPN ensemble activity in mice during self-paced...
Design and manufacturing challenges of optogenetic neural interfaces: a review
S B Goncalves, J F Ribeiro, A F Silva, R M Costa, and J H Correia
Abstract
Optogenetics is a relatively new technology to achieve cell-type specific neuromodulation with millisecond-scale temporal precision. Optogenetic tools are being developed to address neuroscience challenges, and to improve the knowledge about brain networks, with the ultimate aim of catalyzing new...
Skill Learning Modulates RNA Pol II Poising at Immediate Early Genes in the Adult Striatum.
Galvão-Ferreira P, Lipinski M, Santos F, Barco A, Costa RM.
eNeuro. 2017 Apr 17
Abstract
A multilayered complexity of epigenetic and transcriptional regulatory mechanisms underlies neuronal activity-dependent gene transcription. The regulation of RNA Pol II progression along the transcription cycle, from promoter-proximal poising...